{"id":96554,"date":"2017-05-24T15:40:05","date_gmt":"2017-05-24T13:40:05","guid":{"rendered":"https:\/\/clinical.r-biopharm.com\/news\/adalimumab-monitoring-improves-therapy-success-en\/"},"modified":"2019-02-01T00:54:26","modified_gmt":"2019-01-31T23:54:26","slug":"adalimumab-monitoring-improves-therapy-success-en","status":"publish","type":"post","link":"https:\/\/devclinical.r-biopharm.com\/it\/news\/adalimumab-monitoring-improves-therapy-success-en\/","title":{"rendered":"Adalimumab monitoring improves therapy success (en)"},"content":{"rendered":"<div class=\"wpb-content-wrapper\">[vc_row][vc_column][vc_column_text css=&#8221;.vc_custom_1540394284722{margin-bottom: 0px !important;}&#8221;]<strong>The drug adalimumab is used very successfully in the treatment of various inflammatory diseases. Yet in some patients, the efficacy of this drug decreases over time. We explain why this is so and how drug monitoring can contribute to long-term therapy success.<\/strong><!--more--><\/p>\n<p>Whether for rheumatism, psoriasis, or chronic inflammatory bowel diseases: The drug adalimumab (ADM, trade name Humira\u00ae) has considerably improved the therapy options for many patients. As a human monoclonal antibody it is very effective and well tolerated. Like other so-called TNF-\u03b1 blockers, adalimumab binds to the tumor necrosis factor-alpha (TNF-\u03b1), inhibiting its effect. The body therefore excretes fewer inflammation mediators, and the inflammation is ameliorated. Yet in some patients, adalimumab does not work, or its efficacy decreases over time. Sometimes a dosage increase helps in these cases. The cause for the loss of efficacy may also be that the body has formed antibodies against the drug\u2014known as anti-drug antibodies (ADA). These antibodies neutralize the effect of adalimumab. In this case, the only remedy is to change the medication.<\/p>\n<p>Therapeutic drug monitoring (TDM) can assist physicians in making the right therapy decision. Two tests are decisive in this regard:[\/vc_column_text][mk_icon_box icon=&#8221;&#8221; title=&#8221;Trough level measurement&#8221; icon_color=&#8221;&#8221; icon_circle_color=&#8221;&#8221;]To produce the optimum effect, TNF-\u03b1 blockers like adalimumab must be present in a sufficient concentration in the blood. However, this bioavailability can vary from person to person. As a part of drug monitoring, the trough level concentration in the blood can be tested regularly prior to each new infusion. This testing allows the physician to adjust the dose individually to the patient, ensuring that the drug will produce the optimum effect.[\/mk_icon_box][mk_icon_box icon=&#8221;&#8221; title=&#8221;Antibody measurement&#8221; icon_color=&#8221;&#8221; icon_circle_color=&#8221;&#8221;]If the measured trough level indicates that the adalimumab concentration is less than the therapeutically effective level (&lt;\u00a01\u00a0\u00b5g\/mL), the blood should also be tested for anti-ADM antibodies. The therapy can then be adjusted according to the antibody count: If the concentration of anti-ADM antibodies is low, the dose should be increased or the interval between doses should be reduced. In contrast, patients with a high anti-ADM antibody count should be treated with another medication. The trough level and the antibody count give the physician information that is decisive in the further success of therapy. Accordingly we have expanded our portfolio, and, in addition to <a href=\"https:\/\/devclinical.r-biopharm.com\/products\/ridascreen-adm-monitoring\/\">RIDASCREEN\u00ae ADM Monitoring<\/a> (Art. No. G09043), we now offer <a href=\"https:\/\/devclinical.r-biopharm.com\/products\/ridascreen-anti-adm-antibodies\/\">RIDASCREEN\u00ae Anti-ADM Antibodies<\/a> (Art. No. G09044).[\/mk_icon_box][vc_cta h2=&#8221;Hai domande?&#8221; shape=&#8221;square&#8221; style=&#8221;flat&#8221; add_button=&#8221;right&#8221; btn_title=&#8221;Contattaci&#8221; btn_style=&#8221;flat&#8221; btn_shape=&#8221;square&#8221; btn_color=&#8221;inverse&#8221; btn_link=&#8221;url:mailto%3Asales%40r-biopharm.de|&#8221;]Do you have further questions concerning adalimumab and therapeutic drug monitoring? We will be happy to support you![\/vc_cta][\/vc_column][\/vc_row]\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text css=&#8221;.vc_custom_1540394284722{margin-bottom: 0px !important;}&#8221;]The drug adalimumab is used very successfully in the treatment of various inflammatory diseases. Yet in some patients, the efficacy of this drug decreases over time. We explain why this is so and how drug monitoring can contribute to long-term therapy success.<\/p>\n","protected":false},"author":27,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"content-type":"","_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[476,478,479],"tags":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Adalimumab Monitoring Improves Therapy Success<\/title>\n<meta name=\"description\" content=\"Adalimumab is used successfully in the treatment of inflammatory diseases. Yet in some patients the efficacy decreases over time. Learn why and what to do.\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Adalimumab Monitoring Improves Therapy Success\" \/>\n<meta property=\"og:description\" content=\"Adalimumab is used successfully in the treatment of inflammatory diseases. Yet in some patients the efficacy decreases over time. Learn why and what to do.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/devclinical.r-biopharm.com\/it\/news\/adalimumab-monitoring-improves-therapy-success-en\/\" \/>\n<meta property=\"og:site_name\" content=\"\ud83d\udea8\ud83d\udea8\ud83d\udea8 Staging!!! 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